Chris Leak started his football career at Independence High School in Charlotte. Leak led his team to three consecutive North Carolina 4-A state championships and losing only once as a starter under head coach Tommy Knotts. He set North Carolina state records for passing yards in a career (15,593) and completions in a career (1,013), as well as the national record for touchdown passes in a career (185). He was recognized as a Parade magazine All-American as well as Parade's Player of the Year in 2003. The recruiting service ranked Leak as a five-star prospect and the third-best quarterback in the 2003 recruiting class.

In his senior season at UF Chris lead the Gators to their first SEC Championship since 2000, and a spot in the 2007 BCS National Championship Game against The Ohio State University (the Gators' first championship game appearance since 1996). Leak also broke many Gators' passing records set by Heisman Trophy-winner Danny Wuerffel, including Wuerffel's record for career passing yards set during the 2006 SEC championship game.

Leak led the Florida Gators to their second consensus national championship with a 41–14 victory over the Ohio State Buckeyes on January 8, 2007, taking home the offensive Most Valuable Player (MVP) award for the game. His performance was solid throughout the BCS championship game, completing his first nine passes at the start of the game, and finishing with twenty-five completions in thirty-six attempts for 213 yards and one touchdown.

Leak played for the Chicago Bears, and is now the quarterback for the Jacksonville Sharks AFL team.